Dangerous misuse of sulphonylureas.

Sulphonylureas and hypoglycaemia.

Potentially dangerous misuse of the Hartford once-daily nomogram for gentamicin.

Sir, Much of the gentamicin prescribed in the UK is given once daily and can be controlled by using the Hartford nomogram. Using the Hartford method gives time for assay of the blood sample before the next dose is due to be given, allowing appropriate dose modification to be made if necessary. This is not possible with control of therapy by ascertaining pre-dose levels. As clearly stated by its...

Toxic effects of four sulphonylureas herbicides on soil microbial biomass.

The effect of four triazinyl-sulfonylurea herbicides (cinosulfuron, prosulfuron, thifensulfuron methyl, triasulfuron) on soil microbial biomass, soil respiration, metabolic activity, metabolic quotient, and some enzymatic activities (acid and alkaline phosphatase, β-glucosidase, arylsulphatase, and fluorescein diacetate hydrolysis) were monitored under controlled conditions over 30 days. The he...

Optimal utilisation of sulphonylureas in resource-constrained settings

Sulphonylureas (SUs) are oral anti-diabetic drugs (OADs) that were introduced more than 60 years ago. Clinicians are familiar with their use and they remain extensively used. However, the SU class is associated with adverse effects of weight gain and hypoglycaemia. In addition, their effects on cardiovascular events remain contentious. Newer classes of anti-diabetic agents have been developed a...

Study on Dangerous Signal Mining of Dangerous Goods Transport Vehicles

Dangerous signal mining method of dangerous goods transport vehicles and how to improve the accuracy of the mining are studied in the paper. There are many dangerous conditions such as high temperature, high pressure and other dangerous condition caused by the influence of the external factors such as friction in the transportation process of dangerous goods. If people can discover these danger...